The Next Big Thing in Preventive & Personalized Health in 2025 Will Be...

A happy and healthy 2025 to you all!

Last week, I had lunch with my 98-year-old grandfather at his nursing home to celebrate the new year. Longevity genes run strong in my family – at 98, he remains sharp as ever, making jokes and telling me WW2 stories. As I looked around at the fifty other nursing home residents, most in vegetative states, I had a striking realization: this isn't how aging will look in ten years. We're living through a moment where medical advances are about to fundamentally transform the aging process and how we'll look, think, and feel at 80, 90…and beyond.

The signs of the preventative health revolution are everywhere at this start of the year: from Netflix's launch of “Don't Die" (the documentary following controversial tech entrepreneur Bryan Johnson's $2M/year quest to reduce his biological age), to RFK’s impending war on ultra-processed foods, the U.S. Surgeon General’s recent advisory linking alcohol to cancer risk, or the emerging research on GLP-1s' potentially transformative impact on everything from metabolic health to neurodegeneration. 2025 promises to be yet a watershed year for preventive and personalized medicine.

In this special edition, I have gathered insights from 15 of the most respected experts in preventative medicine, personalized health, and longevity to share their visions for 2025. (Credit where it's due: this format is inspired by Nikhil Basu's excellent "the next big thing"yearly newsletter which explores broader tech trends).

Thank you to Tom Latkovic, Nikolina Lauc, Sebastian Brunemeier, Phil Newman, Jean-Charles Samuelian-Werve, Michael Geer, Jean Daniel Malan, Christina Farr, Jonathan Swerdlin, Anant Vinjamoori M.D., Sunita Mohanty, Yuta Lee, Jacob Peters, Paul Grewal M.D., and Marc Serota M.D. for their trust and contribution!

…Consumer Health Ownership

Far more focus than ever before about wellness and preventative health, even as the U.S. healthcare system remains focused on "sick care" versus "health care." The cultural zeitgeist is shifting to be more focused on toxins In the home (forever chemicals, etc.), the negative impacts of soda, alcohol, and processed foods; as well as the downsides to our sedentary lifestyles. We've been talking about this shift for a long time -- but I don't believe the system will drive it, as much as we'll see it in the realm of health and wellness influencers. There will be "snake oil"