Introduction

Welcome back Vitalians. The VitaDAO team is taking Asia by storm. From Hong Kong to Singapore and Bangkok later in the year! Be sure to catch us there if you’re around.

DeSci Summit Singapore looked incredible with some fantastic talks by VitaDAO, VITAFAST and VITARNA. If you missed it, fear not - the recording can be found here.

As usual, the highlight for August in the aging world has been ARDD, which VitaDAO was proud to sponsor for yet another year. We loved the new tracks that were added on Emerging Technologies and Physics in Aging, run by VitaDAO’s own Max Unfried. In case you missed it, here is a collection of impressions and highlights from the conference by another of our contributors, Kamil Pabis.

Speaking of great conferences, Biomarkers of Aging is fast approaching. We’re always happy to support the amazing organising team and they have been kind enough to offer VITA holders 50% off and community members 30% off registration price!

The offer is only valid until September 30th, with the code, VitaDAO token holders off any ticket -  "VITADAO50". Also anyone in VitaDAO's community -  "VITADAO30".

Longevity Literature Hot Picks

Published Research Papers

Nonlinear dynamics of multi-omics profiles during human aging

This study investigated nonlinear molecular changes in aging through multi-omics profiling of 108 participants aged 25 to 75. It identified key shifts in molecular markers at around 44 and 60 years of age, linked to transitions in immune regulation, metabolism, and disease risk.

Development of an epigenetic clock resistant to changes in immune cell composition

Epigenetic clocks are influenced by the changing composition of immune cells with age. This study found that naive CD8+ T cells appear 15–20 years younger than effector memory T cells in the same individual, suggesting that current epigenetic clocks reflect both aging and immune cell composition. 

p16-dependent increase of PD-L1 stability regulates immunosurveillance of senescent cells

Senescent cells evade immune clearance by upregulating the immune checkpoint protein PD-L1, a process driven by p16, which stabilizes PD-L1 through inhibition of CDK4/6 and reduced degradation. Targeting PD-L1 with activating antibodies enhances the elimination of senescent cells, offering a potential strategy to improve immune surveillance and reduce age-related inflammation.

The circadian rhythm: A key variable in aging?

This study used bulk RNA sequencing across multiple organs, mouse strains, and age groups to identify common age-related transcriptional changes, highlighting