Introduction

Welcome back Vitalians!

VitaDAO is excited to announce the launch of VitaLabs - our new Venture Studio, comprising an in-house network of interdisciplinary scientists dedicated to generating novel IP with a view to extending human healthspan.

And to kick-start, we are introducing the VitaLabs Fellowship Program, offering a unique opportunity for you to break free from rigid academic structures and push the frontier of longevity science! Join us in accelerating longevity research!
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Longevity Literature Hot Picks

Pre-print Corner

Systemic extracellular acidification is a hallmark of aging

Published Research Papers

Targeted partial reprogramming of age-associated cell states improves markers of health in mouse models of aging

This study explores a targeted gene therapy approach to slow aging and extend lifespan by delivering specific genes (OSK) to reprogram aged or stressed cells in mice. The therapy improved health markers, delayed aging signs, and extended lifespan without causing tumors, showing potential for future treatments to enhance human health and resilience in aging.

Probabilistic inference of epigenetic age acceleration from cellular dynamics

This research highlights limitations in current epigenetic clocks used to measure biological aging, as they can be influenced by factors unrelated to aging. To improve accuracy, the researchers developed a new model that distinguishes between two key processes, acceleration and bias, which more directly reflect cellular changes and better correlate with factors affecting aging like smoking and alcohol consumption.

Fundamental equations linking methylation dynamics to maximum lifespan in mammals

This study explores how the rate of change in DNA methylation relates to maximum lifespan across various mammal species. The findings show that in specific chromatin regions, there is an inverse relationship between methylation rate and lifespan, with younger animals' methylation patterns reflecting those of older animals, but the overall methylation level doesn't correlate with lifespan.

Rejuvenation of aged oocyte through exposure to young follicular microenvironment

This study shows that the aging of follicular somatic cells, which support oocyte development, may contribute to fertility decline. By transplanting aged oocytes into young follicles, researchers demonstrated improved oocyte maturation, mitochondrial function, and developmental potential, suggesting that future therapies targeting these somatic cells could help treat female infertility.

Hematopoietic aging promotes cancer by fueling IL-1⍺–driven emergency myelopoiesis

This study reveals that aging of the immune system, rather than the age of the tumor itself, promotes lung cancer progression by increasing the production of inflammatory cells that accelerate